The evidence was limited (and at risk of bias ) regarding significantly increased risks of postpartum haemorrhage, stillbirth, impaired motor and intellectual development. of preterm birth (high risk of bias), tremor, hypoglycaemia, decrease in Apgar scores at 1 and 5 minutes, admission to neonatal intensive care units and persistent pulmonary hypertension in neonates.
congenital heart defects: paroxetine, fluoxetine, sertraline,.major congenital malformations: selective serotonin reuptake inhibitors, paroxetine, fluoxetine, no evidence for sertraline, 8 meta-analyses),.This meta-review has highlighted consistent data on the risk to the fetus and newborn from exposure to antidepressants during pregnancy, with a significantly increased risk: Overall, 51 meta-analyses were included (all assessed the risks, and one the benefits of antidepressant use during pregnancy). This meta-review followed domain-specific recommendations providing a particular robust methodological quality. Hence the interest of relying on the meta-analyses carried out on this subject and evaluating them via a meta-review to gain statistical power.Ī meta-review of the literature was performed using the PubMed and Web of Science databases on Octoto identify meta-analyses that assessed associations between antidepressant use during pregnancy and the effects on the health of the pregnant woman, the embryo, the fetus, the newborn and the development of the child. Several studies have investigated the potential harmful effects of taking antidepressants during pregnancy and have shown low absolute risks and sometimes conflicting results. For safety reasons, about half of women would stop their antidepressant treatment before becoming pregnant or during the first trimester. In Europe, the prescription rate would be between 2.3 and 3.3% for serotonin inhibitors – the most prescribed class of antidepressants during this period. The increase in antidepressant prescriptions during pregnancy has been constant over the past decades. In France, the Elfe study revealed that approximately 12% of pregnant women reported antenatal psychological distress (depressive, anxiety, severe mental disorders, addiction and misuse of alcohol or psychoactive substances, etc.) 1.
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